Human Angiopoietin-1 EasyTestTM ELISA kit

Brand

BioAim Scientific (Kanada)

short description

The BioAim Human Angiopoietin-1 EasyTest™ ELISA kit can quantitatively measure human Angiopoietin-1 in serum and plasma. It is a simple and rapid technology for the quantitation of antigen in a range of sample matrices. The whole process takes only 1.5 hours with high accuracy and precision. EasyTestTM ELISA is faster and easier to perform than standard format ELISA with less reagent handling and fewer pipetting steps.
Research Area Angiogenesis; inflammation;

specific against

Human

detection target

angiopoietin 1(Angiopoietin-1)
Background: Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. Angiopoietins, Ang-1, Ang-2, and Ang-3 (mouse)/Ang-4 (human), are natural agonists or antagonists of the Tie-2 receptor tyrosine kinase and are important modulators of angiogenesis. Two domains characterize the angiopoietin family of proteins: an N-terminal coiled-coil domain that mediates homo-oligomerization, and a C-terminal fibrinogen-like domain that binds Tie-2 The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart.

alias

AGP1, AGPT, ANG1

sensitivity

17 pg/ml

detection range

98.3-24000 pg/ml

sample type

Serum

pack size

1x96 Wells

Assay time

1.5 h

Principle of the Elisa

Sandwich ELISA

SwissProtID

Q15389