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EGFR Signaling Pathway

EGF (epidermal growth factor) is the founding member of the EGF family of proteins, which also include Amphiregulin (AREG), Betacellulin (BTC), Epiregulin (EPR), HB-EGF, Neuregulins, and others. Members of epidermal growth factor family have highly similar structural and functional characteristics. They have at least one common structural motif, the EGF domain, which consists of six conserved cysteine residues forming three disulfide bonds. The main structure of EGF domain is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet. In addition to their EGF domain, the epidermal growth factor family members are characterized by two features: Production of mitogenic responses in EGF-sensitive cells, and high affinity binding to the EGF receptor.

The activity of epidermal growth factor family members is mediated by the epidermal growth factor receptor tyrosine kinases (EGFR/ErbB). Members of the EGFR/ErbB family are made up of an extracellular region or ectodomain that contains approximately 620 amino acids, a single transmembrane spanning region and a cytoplasmic tyrosine kinase domain. The extracellular domain of the EGF receptor is characterized by its capacity to bind EGF and EGF-like ligands with high affinity. Chemically this portion of the receptor contains 10-11 N-linked oligosaccharide chains, high content of half-cystine residues (10%) that could give rise to as many as 25 disulfides. The region between the two half-cystine-rich clusters is involved in ligand binding. The hallmark of the cytoplasmic portion of epidermal growth factor receptor is the sequence defining the tyrosine kinase domain. Near the carboxyl terminus of the receptor are four sites of EGF-dependent autophosphorylation.Epidermal growth factor plays an important role in the regulation of cell growth, proliferation, and differentiation.

EGF EGFR Muc1 beta -Catenin E-Cadherin Cytoskeletal Regulation STAT1 STAT1 STAT1 STAT1 STAT3 STAT3 STAT3 STAT3 Jak1/2 Jak1/2 c-Src Actin Cytoskeletal Rearrangemant Rho Pathway Rho Rac1 Vav Nck c-Cbl SHC GRB2 SOS Pl3K PIP3 PAK1 MEKK1 MKK4/7 JNKs c-Fos c-Jun EGFR Endocytosis PIP2 PDK1 AKT Mdm2 P53 mTOR S6K Protein Synthesis Apoptosis Caspase XIAP c-Myc Elk1 NF-kB ERK1/2 MEKK1/2 Raf Ras PLC PIP2 DAG PKC IKK CaMK Ca2+ IP3 Gene Expression

EGFR Signaling Pathway from A to Z

Akt search result
Ca2+ search result
CaMK search result
Caspase search result
c-Cbl search result
c-Fos search result
c-Jun search result
c-Myc search result
c-Src search result
EGF search result
EGFR search result
Elk1 search result
ERK1/2 search result
GRB2 search result
IKK search result
Jak1/2 search result
JNKs search result
Mdm2 search result
MEKK1 search result
MEKK1/2 search result
MKK4/7 search result
mTOR search result
Nck search result
NF-kB search result
P53 search result
PAK1 search result
PDK1 search result
PIP2 search result
PIP3 search result
PKC search result
Pl3K search result
PLC search result
Rac1 search result
Raf search result
Ras search result
Rho search result
S6K search result
SHC search result
SOS search result
STAT1 search result
STAT3 search result
Vav search result
XIAP search result
Muc1 search result
beta -Catenin search result
E-Cadherin search result
Cytoskeletal Regulation search result
Actin Cytoskeletal Rearrangemant search result
Rho Pathway search result
EGFR Endocytosis search result
Protein Synthesis search result
Apoptosis search result
DAG search result
IP3 search result
Gene Expression search result

Thanks to Sino Biological for providing the pathways.