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Canine MMP-8 ELISA Kit

Product Code: BAS-3060114

Verfügbarkeit: Auf Lager

Canine MMP-8 ELISA Kit

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Beschreibung

Details

Canine MMP-8 ELISA Kit

Brand

BioAim Scientific (Kanada)

short description

The Bioaim Canine MMP-8 ELISA kit is a solid phase sandwich ELISA (enzyme-linked immunosorbent assay) for the quantitative measurement of MMP-8 in canine serum, plasma and cell culture media. An antibody specific for canine MMP-8 was coated on a 96-well plate. Standards and samples are added to the wells and any MMP-8 present binds to the immobilized antibody. The wells are washed and biotinylated anti-canine MMP-8 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is added to the wells. The wells are again washed and TMB substrate solution is added, which produces a blue color in direct proportion to the amount of MMP-8 present in the initial sample. The Stop Solution changes the color from blue to yellow, and the microwell absorbances are read at 450 nm.
Research Area Angiogenesis; Cancer Biomarker;

specific against

Canine

detection target

matrix metallopeptidase 8 ( MMP-8 )
Background: Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in the connective tissue of most mammals. Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-8 (neutrophil collagenase, collagenase 2) is expressed in neutrophils, where it is stored in specific granules. MMP-8 release from the neutrophils is stimulated by various factors such as interleukins 1 and 8, TNF-alpha and GM-CSF. MMP-8 is capable of cleaving types I, II, and III triple-helical collagen, gelatin peptides, fibronectin, proteoglycans, aggrecan, serpins, beta -casein, and peptides such as angiotensin and substance P. In addition to its function in phagocytosis, MMP-8 has a high capacity for infiltrating connective tissue and is implicated in the breakdown of the extracellular matrix in diseases such as rheumatoid arthritis.

sensitivity

8 pg/ml

detection range

8.2-6000 pg/ml

sample type

Serum, plasma, Cell culture supernatant

pack size

1x96 Wells

Assay time

4.5 h

Principle of the Elisa

Sandwich ELISA

SwissProtID

F1PVR0

Weitere Informationen

Weitere Informationen

Menge 1x96 Wells
Hersteller BioAim Scientific
Herstellerland Kanada
Sensitivity 8 pg/ml
Specific Against Canine
Antigen Name matrix metallopeptidase 8
Detection Range 8.2-6000 pg/ml
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