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AKT-Signaling-Pathway

The Akt Pathway, or PI3K-Akt Pathway is involved in fundamental cellular processes including protein synthesis, proliferation and survival. AKT also plays a regulatory role in angiogenesis and metabolism. The AKT pathway is activated by factors that induce PI3K which in turn activates mTOR pathways. The AKT signaling pathway plays an important regulatory role in many cellular survival pathways, primarily as an inhibitor of apoptosis. AKT signaling has been implicated in various cancers and is an active area of interest for anti-cancer therapeutics. The pathway can be activated by a range of signals, including hormones, growth factors and components of the extracellular matrix (ECM). PI3K can also be activated by G protein-coupled receptors (GPCR). Akt binds PIP3 through its pleckstrin homology (PH) domain, resulting in translocation of Akt to the membrane. PDK1, which is also brought to the membrane through its PH domain, phosphorylates Akt within its activation loop at Thr308. A second phosphorylation at Ser473 within the carboxy terminus is also required for activity and is carried out by the mTOR-rictor complex, mTORC2. AKT is activated by PI3K, which itself is activated by several upstream signaling pathways such as insulin receptors, receptor tyrosine kinases, G protein coupled receptors, cytokine receptors, etc. After activation, it targets several downstream molecules and change their activity by phosphorylation or complex formation. AKT is involved in cell proliferation, glucose metabolism, cell survival, cell cycle, protein synthesis, and in neuronal morphology and plasticity by regulation of several downstream molecules shown in this figure. AKT is involved in cell proliferation through interaction with a number of proteins involved in cell cycle Akt is also a key player in cardiovascular disease through its role in cardiac growth, angiogenesis, and hypertrophy. The pathway is highly regulated by multiple mechanisms, often involving cross-talk with other signalling pathways.

GABAR GPCR Growth Factor Integrin Cytokin Receptor BCR Synaptio Signaling Gbeta1/2 P13K G alpha GTP Ras PTEN PIP3 P13K GAB1 GAB2 IRS1 pDK1 AKT AKT FAK Paxillin P13K DNAPK ILK PIP3 Jak1 P13K pDK1 PTEN Syk BCAP Cell cycle Glycogen Synthesis Glycogen Synthase Glucose Transport Cyclin D1 CTMP PHLPP PP2A HSP90 WEE1 Myt1 P27 Kip CDC37 P21 Cip GSK3 PIP5K AS160 PFKFB2 eNOS Htt WNK-1 YAP AR Tpl2 IKK alpha LaminA Ataxin-1 ASK1 JIP1 CREB MDM2 P53 Bax Bcl2 Bim Fox01 FKHR 14-3-3 14-3-3 FKHR CREB BAD BAD Pras40 elF4E 4EBP1 mTOR TSC1 TSC2 Raf1 XIAP P70S6K PDCD4 S6 Caspase 9 PDE3B Aggregation Neurodegeneration Caspase Casscade Transtation Regulation of Cyclic Nacleotide Blocks Apoptosis Protein Synthesis ERK  Pathway Death Genes Survival Genes Apoptosis JNK Pathway Organization of Nuclear Proteins NF-kB Pathway Glycolysis Cardiovascolar Homeostasis P 73 Mediated Apoptosis Cell Survival Cell Survival Neuroprotectin Insulin Stimulated Mitogenesis

Akt-Signaling-Pathway from A to Z

SINGLE COMPONENTS PRODUCTS
37694 search result
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Thanks to Sino Biological for providing the pathways.