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Actin Dynamics Signaling Pathway

Extracellular signals regulate actin dynamics through G protein-coupled receptors (GPCRs), integrins, and receptor tyrosine kinases (RTKs). GPCRs constitute a large protein family of receptors, that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. Integrins are transmembrane receptors that are the bridges for cell-cell and cell-extracellular matrix (ECM) interactions. When triggered, integrins in turn trigger chemical pathways to the interior (signal transduction), such as the chemical composition and mechanical status of the ECM, which results in a response (activation of transcription) such as regulation of the cell cycle, cell shape, and/or motility; or new receptors being added to the cell membrane. Receptor tyrosine kinase (RTK) is part of the larger family of protein tyrosine kinase. Receptor tyrosine kinase consists of EGFR, PDGFR, MCSFR, IGF1R, INSR, NGFR, FGFR, VEGFR and HGFR. Intracellular signals regulate of the cell's response to external cues occurs through Rho. Rho is a member of the Ras superfamily of small GTP-binding proteins that play a central role in diverse biological processes such as Actin cytoskeleton organization, Microtubule dynamics, Gene transcription, Oncogenic transformation, Cell cycle progression, Adhesion and Epithelial wound repair. GEF(guanine nucleotide exchange factors) is activator. ROCK and PAK are downstream protein kinase effectors. Aberrant control of cytoskeletal signaling, which can result in a disconnection between extracellular stimuli and cellular responses, is often seen in immune pathologies, developmental defects, and cancer.

GPCR RhoGEF VASP PKA Ena PKC PIP2 PLC RTK p13K p13K Integrins Paxillin Src FAK Confilin PIP3 GRB2 GRB2 Nck Fascin CaM PAK1 WASP PIP3 GEF GIT P130 Crk PIX Ras p13K VAV Rac Cortactin Arp2/3 WAVE PIP2 GSN PIK Lamellipodia CaM 14-3-3 SSH PKD1 Confilin LIMK Calcineurin PI5K ROCK PAK1 MLCK CIN Hsp90 Actin Polymerization CapZ Tmod Filopodia mDIA Arp2/3 WASP cdc42 PAK1 MLC MLCK MEK MEKK Filopodia Rho mDIA Profilin ROCk MBS Filamin Lamellipodia Stress Fibers Degradation

Actin Dynamics Signaling Pathway from A to Z

SINGLE COMPONENTS PRODUCTS
14-3-3 search result
Actin Polymerization search result
Arp2/3 search result
Calcineurin search result
CaM search result
CapZ search result
cdc42 search result
CIN search result
Confilin search result
Cortactin search result
Crk search result
Degradation search result
Ena search result
FAK search result
Fascin search result
Filamin search result
Filopodia search result
GEF search result
GIT search result
GPCR search result
GRB2 search result
GSN search result
Hsp90 search result
Integrins search result
Lamellipodia search result
LIMK search result
MBS search result
mDIA search result
MEK search result
MEKK search result
MLC search result
MLCK search result
Nck search result
P130 search result
p13K search result
PAK1 search result
Paxillin search result
PI5K search result
PIK search result
PIK search result
PIP2 search result
PIP3 search result
PKA search result
PKC search result
PKD1 search result
PLC search result
Profiln search result
Rac search result
Ras search result
Rho search result
RhoGEF search result
ROCK search result
RTK search result
Src search result
SSH search result
Stress Fibers search result
Tmod search result
VASP search result
VAV search result
WASP search result
WAVE search result

Thanks to Sino Biological for providing the pathways.